BDBM349050 N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 168

SMILES: FC1(F)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12

InChI Key: InChIKey=UVEOCFIRZHIOLL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 349050   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
JAK1 (aa 850-1154) (Homo sapiens (Human))	BDBM349050 (N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...) Show SMILES FC1(F)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H21F2N5O2/c23-22(24)10-12-28(13-11-22)20(31)16-8-4-14(5-9-16)17-2-1-3-18-25-21(27-29(17)18)26-19(30)15-6-7-15/h1-5,8-9,15H,6-7,10-13H2,(H,26,27,30)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM349050 (N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...) Show SMILES FC1(F)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H21F2N5O2/c23-22(24)10-12-28(13-11-22)20(31)16-8-4-14(5-9-16)17-2-1-3-18-25-21(27-29(17)18)26-19(30)15-6-7-15/h1-5,8-9,15H,6-7,10-13H2,(H,26,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	923	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition of JAK3 (unknown origin) in presence of ATP at Km concentration by caliper assay				Bioorg Med Chem Lett 11: 1599-603 (2001)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM349050 (N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...) Show SMILES FC1(F)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H21F2N5O2/c23-22(24)10-12-28(13-11-22)20(31)16-8-4-14(5-9-16)17-2-1-3-18-25-21(27-29(17)18)26-19(30)15-6-7-15/h1-5,8-9,15H,6-7,10-13H2,(H,26,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	401	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin) in presence of ATP at Km concentration by caliper assay				Bioorg Med Chem Lett 11: 1599-603 (2001)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM349050 (N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...) Show SMILES FC1(F)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H21F2N5O2/c23-22(24)10-12-28(13-11-22)20(31)16-8-4-14(5-9-16)17-2-1-3-18-25-21(27-29(17)18)26-19(30)15-6-7-15/h1-5,8-9,15H,6-7,10-13H2,(H,26,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	393	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition of JAK1 (unknown origin) in presence of ATP at Km concentration by caliper assay				Bioorg Med Chem Lett 11: 1599-603 (2001)
					More data for this Ligand-Target Pair