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SMILES: CC1(C)CCCN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12

InChI Key: InChIKey=SDOKZTLOFXSRHF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 349057   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349057
PNG
(N-(5-(4-(3,3- dimethylpiperidine-1- carbonyl)pheny...)
Show SMILES CC1(C)CCCN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C24H27N5O2/c1-24(2)13-4-14-28(15-24)22(31)18-11-7-16(8-12-18)19-5-3-6-20-25-23(27-29(19)20)26-21(30)17-9-10-17/h3,5-8,11-12,17H,4,9-10,13-15H2,1-2H3,(H,26,27,30)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair