BDBM349497 (4R)-6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-4-methyl-1,3,4,5-tetrahydropyrido[3,4-b][1,4]diazepin-2-one::US10206931, Example 305

SMILES: CN\C=C(/C=N)c1cc2CCCN(c2cc1C(F)F)c1nccc2NC(=O)C[C@@H](C)Nc12

InChI Key: InChIKey=GJKHZZAQAHWIBX-XWPNNCTASA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349497   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD4 BD1 (aa 42-168) (Homo sapiens (Human))	BDBM349497 ((4R)-6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl...) Show SMILES CN\C=C(/C=N)c1cc2CCCN(c2cc1C(F)F)c1nccc2NC(=O)C[C@@H](C)Nc12 |r| Show InChI InChI=1S/C23H26F2N6O/c1-13-8-20(32)30-18-5-6-28-23(21(18)29-13)31-7-3-4-14-9-16(15(11-26)12-27-2)17(22(24)25)10-19(14)31/h5-6,9-13,22,26-27,29H,3-4,7-8H2,1-2H3,(H,30,32)/b15-12+,26-11?/t13-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...				US Patent US10206931 (2019) BindingDB Entry DOI: 10.7270/Q2GM89FR
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM349497 ((4R)-6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl...) Show SMILES CN\C=C(/C=N)c1cc2CCCN(c2cc1C(F)F)c1nccc2NC(=O)C[C@@H](C)Nc12 |r| Show InChI InChI=1S/C23H26F2N6O/c1-13-8-20(32)30-18-5-6-28-23(21(18)29-13)31-7-3-4-14-9-16(15(11-26)12-27-2)17(22(24)25)10-19(14)31/h5-6,9-13,22,26-27,29H,3-4,7-8H2,1-2H3,(H,30,32)/b15-12+,26-11?/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				US Patent US10206931 (2019) BindingDB Entry DOI: 10.7270/Q2GM89FR
					More data for this Ligand-Target Pair