BDBM349709 2-[(4-{6-[(4-Cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperazin-1-yl)methyl]-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid::US10208019, Example 5A-01

SMILES: OC(=O)c1ccc2nc(CN3CCN(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1

InChI Key: InChIKey=MHGRIBXIKDJHKB-QHCPKHFHSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349709   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349709 (2-[(4-{6-[(4-Cyano-2-fluorobenzyl)oxy]pyridin-2-yl...) Show SMILES OC(=O)c1ccc2nc(CN3CCN(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 Show InChI InChI=1S/C30H29FN6O4/c31-24-14-20(16-32)4-5-22(24)19-41-29-3-1-2-27(34-29)36-11-9-35(10-12-36)18-28-33-25-7-6-21(30(38)39)15-26(25)37(28)17-23-8-13-40-23/h1-7,14-15,23H,8-13,17-19H2,(H,38,39)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.40	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349709 (2-[(4-{6-[(4-Cyano-2-fluorobenzyl)oxy]pyridin-2-yl...) Show SMILES OC(=O)c1ccc2nc(CN3CCN(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 Show InChI InChI=1S/C30H29FN6O4/c31-24-14-20(16-32)4-5-22(24)19-41-29-3-1-2-27(34-29)36-11-9-35(10-12-36)18-28-33-25-7-6-21(30(38)39)15-26(25)37(28)17-23-8-13-40-23/h1-7,14-15,23H,8-13,17-19H2,(H,38,39)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.340	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair