BDBM349743 2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-yl}-2-methylpiperazin-1-yl]methyl}-1-(1,3-oxazol-4-ylmethyl)-1H-benzimidazole-6-carboxylic acid::US10208019, Example 10A-13

SMILES: C[C@H]1CN(CCN1Cc1nc2ccc(cc2n1Cc1cocn1)C(O)=O)c1cccc(OCc2ccc(Cl)cc2F)n1

InChI Key: InChIKey=XVNUBAZDBSFGQA-IBGZPJMESA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349743   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349743 (2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...) Show SMILES C[C@H]1CN(CCN1Cc1nc2ccc(cc2n1Cc1cocn1)C(O)=O)c1cccc(OCc2ccc(Cl)cc2F)n1 Show InChI InChI=1S/C30H28ClFN6O4/c1-19-13-37(27-3-2-4-29(35-27)42-16-21-5-7-22(31)12-24(21)32)10-9-36(19)15-28-34-25-8-6-20(30(39)40)11-26(25)38(28)14-23-17-41-18-33-23/h2-8,11-12,17-19H,9-10,13-16H2,1H3,(H,39,40)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349743 (2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...) Show SMILES C[C@H]1CN(CCN1Cc1nc2ccc(cc2n1Cc1cocn1)C(O)=O)c1cccc(OCc2ccc(Cl)cc2F)n1 Show InChI InChI=1S/C30H28ClFN6O4/c1-19-13-37(27-3-2-4-29(35-27)42-16-21-5-7-22(31)12-24(21)32)10-9-36(19)15-28-34-25-8-6-20(30(39)40)11-26(25)38(28)14-23-17-41-18-33-23/h2-8,11-12,17-19H,9-10,13-16H2,1H3,(H,39,40)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.10	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair