Found 6 hits for monomerid = 350070 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM350070
(US10208024, Example 69 | US10766881, Example 69)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CCN(C)C)c1 |(10.83,-.21,;9.5,-.98,;8.16,-.21,;8.16,1.33,;6.83,2.1,;6.83,3.64,;8.16,4.41,;5.5,1.33,;4.16,2.1,;5.5,-.21,;6.83,-.98,;6.83,-2.52,;4.16,-.98,;2.83,-.21,;1.49,-.98,;1.49,-2.52,;2.83,-3.29,;4.16,-2.52,;5.5,-3.29,;.16,-.21,;-1.17,-.98,;-2.51,-.21,;-2.51,1.33,;-1.17,2.1,;.16,1.33,;1.49,2.1,;-3.84,-.98,;-3.84,-2.52,;-5.31,-2.99,;-6.21,-1.75,;-7.75,-1.75,;-8.52,-3.08,;-10.06,-3.08,;-10.83,-4.41,;-10.83,-1.75,;-5.31,-.5,)| Show InChI InChI=1S/C23H24Cl2N8O3/c1-31(2)7-8-32-12-13(10-28-32)15-11-27-23(26)21(29-15)14-5-6-18(34)33(30-14)22-19(24)16(35-3)9-17(36-4)20(22)25/h5-6,9-12H,7-8H2,1-4H3,(H2,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM350070
(US10208024, Example 69 | US10766881, Example 69)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CCN(C)C)c1 |(10.83,-.21,;9.5,-.98,;8.16,-.21,;8.16,1.33,;6.83,2.1,;6.83,3.64,;8.16,4.41,;5.5,1.33,;4.16,2.1,;5.5,-.21,;6.83,-.98,;6.83,-2.52,;4.16,-.98,;2.83,-.21,;1.49,-.98,;1.49,-2.52,;2.83,-3.29,;4.16,-2.52,;5.5,-3.29,;.16,-.21,;-1.17,-.98,;-2.51,-.21,;-2.51,1.33,;-1.17,2.1,;.16,1.33,;1.49,2.1,;-3.84,-.98,;-3.84,-2.52,;-5.31,-2.99,;-6.21,-1.75,;-7.75,-1.75,;-8.52,-3.08,;-10.06,-3.08,;-10.83,-4.41,;-10.83,-1.75,;-5.31,-.5,)| Show InChI InChI=1S/C23H24Cl2N8O3/c1-31(2)7-8-32-12-13(10-28-32)15-11-27-23(26)21(29-15)14-5-6-18(34)33(30-14)22-19(24)16(35-3)9-17(36-4)20(22)25/h5-6,9-12H,7-8H2,1-4H3,(H2,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3 [397-806]
(Homo sapiens (Human)) | BDBM350070
(US10208024, Example 69 | US10766881, Example 69)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CCN(C)C)c1 |(10.83,-.21,;9.5,-.98,;8.16,-.21,;8.16,1.33,;6.83,2.1,;6.83,3.64,;8.16,4.41,;5.5,1.33,;4.16,2.1,;5.5,-.21,;6.83,-.98,;6.83,-2.52,;4.16,-.98,;2.83,-.21,;1.49,-.98,;1.49,-2.52,;2.83,-3.29,;4.16,-2.52,;5.5,-3.29,;.16,-.21,;-1.17,-.98,;-2.51,-.21,;-2.51,1.33,;-1.17,2.1,;.16,1.33,;1.49,2.1,;-3.84,-.98,;-3.84,-2.52,;-5.31,-2.99,;-6.21,-1.75,;-7.75,-1.75,;-8.52,-3.08,;-10.06,-3.08,;-10.83,-4.41,;-10.83,-1.75,;-5.31,-.5,)| Show InChI InChI=1S/C23H24Cl2N8O3/c1-31(2)7-8-32-12-13(10-28-32)15-11-27-23(26)21(29-15)14-5-6-18(34)33(30-14)22-19(24)16(35-3)9-17(36-4)20(22)25/h5-6,9-12H,7-8H2,1-4H3,(H2,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| |
US Patent US10766881 (2020)
BindingDB Entry DOI: 10.7270/Q2BZ693Q |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1 [308-731]
(Homo sapiens (Human)) | BDBM350070
(US10208024, Example 69 | US10766881, Example 69)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CCN(C)C)c1 |(10.83,-.21,;9.5,-.98,;8.16,-.21,;8.16,1.33,;6.83,2.1,;6.83,3.64,;8.16,4.41,;5.5,1.33,;4.16,2.1,;5.5,-.21,;6.83,-.98,;6.83,-2.52,;4.16,-.98,;2.83,-.21,;1.49,-.98,;1.49,-2.52,;2.83,-3.29,;4.16,-2.52,;5.5,-3.29,;.16,-.21,;-1.17,-.98,;-2.51,-.21,;-2.51,1.33,;-1.17,2.1,;.16,1.33,;1.49,2.1,;-3.84,-.98,;-3.84,-2.52,;-5.31,-2.99,;-6.21,-1.75,;-7.75,-1.75,;-8.52,-3.08,;-10.06,-3.08,;-10.83,-4.41,;-10.83,-1.75,;-5.31,-.5,)| Show InChI InChI=1S/C23H24Cl2N8O3/c1-31(2)7-8-32-12-13(10-28-32)15-11-27-23(26)21(29-15)14-5-6-18(34)33(30-14)22-19(24)16(35-3)9-17(36-4)20(22)25/h5-6,9-12H,7-8H2,1-4H3,(H2,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| Assay Description
To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660... |
US Patent US10766881 (2020)
BindingDB Entry DOI: 10.7270/Q2BZ693Q |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 2 [403-822]
(Homo sapiens (Human)) | BDBM350070
(US10208024, Example 69 | US10766881, Example 69)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CCN(C)C)c1 |(10.83,-.21,;9.5,-.98,;8.16,-.21,;8.16,1.33,;6.83,2.1,;6.83,3.64,;8.16,4.41,;5.5,1.33,;4.16,2.1,;5.5,-.21,;6.83,-.98,;6.83,-2.52,;4.16,-.98,;2.83,-.21,;1.49,-.98,;1.49,-2.52,;2.83,-3.29,;4.16,-2.52,;5.5,-3.29,;.16,-.21,;-1.17,-.98,;-2.51,-.21,;-2.51,1.33,;-1.17,2.1,;.16,1.33,;1.49,2.1,;-3.84,-.98,;-3.84,-2.52,;-5.31,-2.99,;-6.21,-1.75,;-7.75,-1.75,;-8.52,-3.08,;-10.06,-3.08,;-10.83,-4.41,;-10.83,-1.75,;-5.31,-.5,)| Show InChI InChI=1S/C23H24Cl2N8O3/c1-31(2)7-8-32-12-13(10-28-32)15-11-27-23(26)21(29-15)14-5-6-18(34)33(30-14)22-19(24)16(35-3)9-17(36-4)20(22)25/h5-6,9-12H,7-8H2,1-4H3,(H2,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc.
US Patent
| |
US Patent US10766881 (2020)
BindingDB Entry DOI: 10.7270/Q2BZ693Q |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM350070
(US10208024, Example 69 | US10766881, Example 69)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CCN(C)C)c1 |(10.83,-.21,;9.5,-.98,;8.16,-.21,;8.16,1.33,;6.83,2.1,;6.83,3.64,;8.16,4.41,;5.5,1.33,;4.16,2.1,;5.5,-.21,;6.83,-.98,;6.83,-2.52,;4.16,-.98,;2.83,-.21,;1.49,-.98,;1.49,-2.52,;2.83,-3.29,;4.16,-2.52,;5.5,-3.29,;.16,-.21,;-1.17,-.98,;-2.51,-.21,;-2.51,1.33,;-1.17,2.1,;.16,1.33,;1.49,2.1,;-3.84,-.98,;-3.84,-2.52,;-5.31,-2.99,;-6.21,-1.75,;-7.75,-1.75,;-8.52,-3.08,;-10.06,-3.08,;-10.83,-4.41,;-10.83,-1.75,;-5.31,-.5,)| Show InChI InChI=1S/C23H24Cl2N8O3/c1-31(2)7-8-32-12-13(10-28-32)15-11-27-23(26)21(29-15)14-5-6-18(34)33(30-14)22-19(24)16(35-3)9-17(36-4)20(22)25/h5-6,9-12H,7-8H2,1-4H3,(H2,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor... |
US Patent US10208024 (2019)
BindingDB Entry DOI: 10.7270/Q2CJ8GNW |
More data for this
Ligand-Target Pair | |
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