BDBM350392 (S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin-7-yl)propyl)amino)pyrimidine-5-carbonitrile::US10208066, Compound 6::US10611777, Compound 6

SMILES: CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1

InChI Key: InChIKey=KEDQXZKJNCRCTR-HNNXBMFYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350392   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM350392 ((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...) Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...				US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human))	BDBM350392 ((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...) Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	303	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...				US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM350392 ((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...) Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...				US Patent US10611777 (2020)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM350392 ((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...) Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...				US Patent US10611777 (2020)
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human))	BDBM350392 ((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...) Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	303	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...				US Patent US10611777 (2020)
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human))	BDBM350392 ((S)-4-amino-6-((1-(6-phenylimidazo[1,2-b]pyridazin...) Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C20H17ClN8/c1-2-15(27-20-14(9-22)19(23)25-11-26-20)13-8-17-24-10-16(21)29(17)28-18(13)12-6-4-3-5-7-12/h3-8,10-11,15H,2H2,1H3,(H3,23,25,26,27)/t15-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...				US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W
					More data for this Ligand-Target Pair