new BindingDB logo
myBDB logout

BDBM35047 benzothienopyrimidinone deriv., 20b

SMILES: O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccccc2)C1

InChI Key: InChIKey=RVEDMOLIJBWGQX-HNNXBMFYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35047   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35047
PNG
(benzothienopyrimidinone deriv., 20b)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccccc2)C1 |r|
Show InChI InChI=1S/C21H19N3O2S/c25-15-8-9-24(11-15)12-18-22-19-16-10-14(13-4-2-1-3-5-13)6-7-17(16)27-20(19)21(26)23-18/h1-7,10,15,25H,8-9,11-12H2,(H,22,23,26)/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
3 -11.6n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35047
PNG
(benzothienopyrimidinone deriv., 20b)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccccc2)C1 |r|
Show InChI InChI=1S/C21H19N3O2S/c25-15-8-9-24(11-15)12-18-22-19-16-10-14(13-4-2-1-3-5-13)6-7-17(16)27-20(19)21(26)23-18/h1-7,10,15,25H,8-9,11-12H2,(H,22,23,26)/t15-/m0/s1
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
10 -10.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair