BDBM35058 N-acylpolyamine (NAPA) scaffold, 5

SMILES: CC(C)CCCNC(=O)N(CC(CCC(O)=O)NC(N)=O)C(CCCCN)CN(C(CCC(O)=O)CN(CCC(N)=O)C(=O)NCCCc1ccccc1)C(=O)NCCc1ccc(Br)cc1

InChI Key: InChIKey=CAZKNLQOWMIASN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-Binding Protein HDMX (Homo sapiens (Human))	BDBM35058 (N-acylpolyamine (NAPA) scaffold, 5) Show SMILES CC(C)CCCNC(=O)N(CC(CCC(O)=O)NC(N)=O)C(CCCCN)CN(C(CCC(O)=O)CN(CCC(N)=O)C(=O)NCCCc1ccccc1)C(=O)NCCc1ccc(Br)cc1 Show InChI InChI=1S/C46H73BrN10O9/c1-33(2)10-8-26-52-45(65)56(30-37(54-43(50)63)19-21-41(59)60)38(14-6-7-25-48)32-57(46(66)53-28-23-35-15-17-36(47)18-16-35)39(20-22-42(61)62)31-55(29-24-40(49)58)44(64)51-27-9-13-34-11-4-3-5-12-34/h3-5,11-12,15-18,33,37-39H,6-10,13-14,19-32,48H2,1-2H3,(H2,49,58)(H,51,64)(H,52,65)(H,53,66)(H,59,60)(H,61,62)(H3,50,54,63)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Inhibitory activities of NAPAs were measured by fluorescence anisotropy competition experiments. Protein was incubated with fluorescein-labeled huma...				Bioorg Med Chem 17: 7884-93 (2009) Article DOI: 10.1016/j.bmc.2009.10.032 BindingDB Entry DOI: 10.7270/Q2057D90
					More data for this Ligand-Target Pair
MDM2-MDMX (Homo sapiens (Human))	BDBM35058 (N-acylpolyamine (NAPA) scaffold, 5) Show SMILES CC(C)CCCNC(=O)N(CC(CCC(O)=O)NC(N)=O)C(CCCCN)CN(C(CCC(O)=O)CN(CCC(N)=O)C(=O)NCCCc1ccccc1)C(=O)NCCc1ccc(Br)cc1 Show InChI InChI=1S/C46H73BrN10O9/c1-33(2)10-8-26-52-45(65)56(30-37(54-43(50)63)19-21-41(59)60)38(14-6-7-25-48)32-57(46(66)53-28-23-35-15-17-36(47)18-16-35)39(20-22-42(61)62)31-55(29-24-40(49)58)44(64)51-27-9-13-34-11-4-3-5-12-34/h3-5,11-12,15-18,33,37-39H,6-10,13-14,19-32,48H2,1-2H3,(H2,49,58)(H,51,64)(H,52,65)(H,53,66)(H,59,60)(H,61,62)(H3,50,54,63)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	7.6	23
NIH					Assay Description Inhibitory activities of NAPAs were measured by fluorescence anisotropy competition experiments. Protein was incubated with fluorescein-labeled huma...				Bioorg Med Chem 17: 7884-93 (2009) Article DOI: 10.1016/j.bmc.2009.10.032 BindingDB Entry DOI: 10.7270/Q2057D90
					More data for this Ligand-Target Pair