BDBM35084 N-acylpolyamine (NAPA) scaffold, 35

SMILES: NCCCC[C@@H](CN([C@@H](CCCCN)CN([C@@H](CCCCN)CN(CCC(N)=O)C(=O)NCCCc1ccc(F)cc1)C(=O)NCCc1ccc(Br)cc1)C(=O)NCCCC1CCCCC1)NC(N)=O

InChI Key: InChIKey=YKVVSCKUORRVJW-LCALOIESSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35084   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-Binding Protein HDMX (Homo sapiens (Human))	BDBM35084 (N-acylpolyamine (NAPA) scaffold, 35) Show SMILES NCCCC[C@@H](CN([C@@H](CCCCN)CN([C@@H](CCCCN)CN(CCC(N)=O)C(=O)NCCCc1ccc(F)cc1)C(=O)NCCc1ccc(Br)cc1)C(=O)NCCCC1CCCCC1)NC(N)=O |r| Show InChI InChI=1S/C51H86BrFN12O5/c52-42-23-19-41(20-24-42)27-34-61-51(70)65(45(17-5-8-30-55)37-63(35-28-47(57)66)49(68)59-32-11-15-40-21-25-43(53)26-22-40)38-46(18-6-9-31-56)64(36-44(62-48(58)67)16-4-7-29-54)50(69)60-33-10-14-39-12-2-1-3-13-39/h19-26,39,44-46H,1-18,27-38,54-56H2,(H2,57,66)(H,59,68)(H,60,69)(H,61,70)(H3,58,62,67)/t44-,45-,46-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Inhibitory activities of NAPAs were measured by fluorescence anisotropy competition experiments. Protein was incubated with fluorescein-labeled huma...				Bioorg Med Chem 17: 7884-93 (2009) Article DOI: 10.1016/j.bmc.2009.10.032 BindingDB Entry DOI: 10.7270/Q2057D90
					More data for this Ligand-Target Pair
MDM2-MDMX (Homo sapiens (Human))	BDBM35084 (N-acylpolyamine (NAPA) scaffold, 35) Show SMILES NCCCC[C@@H](CN([C@@H](CCCCN)CN([C@@H](CCCCN)CN(CCC(N)=O)C(=O)NCCCc1ccc(F)cc1)C(=O)NCCc1ccc(Br)cc1)C(=O)NCCCC1CCCCC1)NC(N)=O |r| Show InChI InChI=1S/C51H86BrFN12O5/c52-42-23-19-41(20-24-42)27-34-61-51(70)65(45(17-5-8-30-55)37-63(35-28-47(57)66)49(68)59-32-11-15-40-21-25-43(53)26-22-40)38-46(18-6-9-31-56)64(36-44(62-48(58)67)16-4-7-29-54)50(69)60-33-10-14-39-12-2-1-3-13-39/h19-26,39,44-46H,1-18,27-38,54-56H2,(H2,57,66)(H,59,68)(H,60,69)(H,61,70)(H3,58,62,67)/t44-,45-,46-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIH					Assay Description Inhibitory activities of NAPAs were measured by fluorescence anisotropy competition experiments. Protein was incubated with fluorescein-labeled huma...				Bioorg Med Chem 17: 7884-93 (2009) Article DOI: 10.1016/j.bmc.2009.10.032 BindingDB Entry DOI: 10.7270/Q2057D90
					More data for this Ligand-Target Pair