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BDBM350841 UNC1536A::US9795606, A5

SMILES: CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1

InChI Key: InChIKey=POJHPGOEGZTUPC-XUTJKUGGSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350841   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM350841
PNG
(UNC1536A | US9795606, A5)
Show SMILES CCCCNc1ncc2c(cn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1 |r,wU:13.12,wD:16.16,(-8.57,-3.77,;-7.24,-3,;-5.91,-3.77,;-4.57,-3,;-3.24,-3.77,;-1.91,-3,;-1.91,-1.46,;-.57,-.69,;.76,-1.46,;2.23,-.99,;3.13,-2.23,;2.23,-3.48,;2.62,-4.96,;4.11,-5.36,;5.2,-4.27,;6.69,-4.67,;7.09,-6.16,;8.57,-6.56,;6,-7.25,;4.51,-6.85,;.76,-3,;-.57,-3.77,;2.62,.5,;4.11,.9,;4.51,2.39,;3.42,3.48,;1.93,3.08,;.85,4.17,;1.54,1.59,;3.82,4.96,;2.28,4.96,;3.82,6.5,;5.31,5.36,;6.4,4.27,;7.88,4.67,;8.28,6.16,;7.19,7.25,;5.71,6.85,)|
Show InChI InChI=1S/C27H37FN6O3S/c1-2-3-10-30-27-31-16-22-23(18-33(26(22)32-27)17-19-4-7-21(29)8-5-19)20-6-9-25(24(28)15-20)38(35,36)34-11-13-37-14-12-34/h6,9,15-16,18-19,21H,2-5,7-8,10-14,17,29H2,1H3,(H,30,31,32)/t19-,21-
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US Patent
n/an/a<250n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...

US Patent US9795606 (2017)


BindingDB Entry DOI: 10.7270/Q2FB553D
More data for this
Ligand-Target Pair