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BDBM350871 UNC2433A::US9795606, D2

SMILES: CCCCNc1ncc2n(cc(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1

InChI Key: InChIKey=ULQDYMNINJNEFP-HVTIJUPFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350871   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM350871
PNG
(UNC2433A | US9795606, D2)
Show SMILES CCCCNc1ncc2n(cc(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1 |r,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;1.68,2.68,;3.97,6.05,;2.48,5.66,;2.88,7.14,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)|
Show InChI InChI=1S/C27H37N5O3S/c1-2-3-15-28-27-29-18-25-26(30-27)24(20-7-11-22(33)12-8-20)19-32(25)21-9-13-23(14-10-21)36(34,35)31-16-5-4-6-17-31/h9-10,13-14,18-20,22,33H,2-8,11-12,15-17H2,1H3,(H,28,29,30)/t20?,22-
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US Patent
n/an/a<250n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...

US Patent US9795606 (2017)


BindingDB Entry DOI: 10.7270/Q2FB553D
More data for this
Ligand-Target Pair