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SMILES: Cc1ncc(COc2cc(F)cc(Oc3ccc(cc3)-n3nc(C4CCCC4)c4ncnc(N)c34)c2)cn1

InChI Key: InChIKey=PBBBXUSXYRAQLS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350878   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM350878
PNG
(US9795608, Compound 8)
Show SMILES Cc1ncc(COc2cc(F)cc(Oc3ccc(cc3)-n3nc(C4CCCC4)c4ncnc(N)c34)c2)cn1
Show InChI InChI=1S/C28H26FN7O2/c1-17-31-13-18(14-32-17)15-37-23-10-20(29)11-24(12-23)38-22-8-6-21(7-9-22)36-27-26(33-16-34-28(27)30)25(35-36)19-4-2-3-5-19/h6-14,16,19H,2-5,15H2,1H3,(H2,30,33,34)
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US Patent
<100n/an/an/an/an/an/an/an/a



PHARMASCIENCE, INC.

US Patent


Assay Description
Fluorescence polarization-based kinase assays were performed in 384 well-plate format using histidine tagged recombinant human full-length Bruton Aga...

US Patent US9795608 (2017)


BindingDB Entry DOI: 10.7270/Q29K4DCP
More data for this
Ligand-Target Pair