BDBM350898 8-Chloro-2-ethylthio-3-(2,6-difluorophenyl)-4-oxo-3,4-dihydroquinazoline::US9796687, Compound 18

SMILES: CCSc1nc2c(Cl)cccc2c(=O)n1-c1c(F)cccc1F

InChI Key: InChIKey=BIMQUSGOXKWARK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350898   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM350898 (8-Chloro-2-ethylthio-3-(2,6-difluorophenyl)-4-oxo-...) Show SMILES CCSc1nc2c(Cl)cccc2c(=O)n1-c1c(F)cccc1F |(6.67,-5.39,;8,-4.62,;8,-3.08,;6.67,-2.31,;5.33,-3.08,;4,-2.31,;2.67,-3.08,;2.67,-4.62,;1.33,-2.31,;1.33,-.77,;2.67,,;4,-.77,;5.33,,;5.33,1.54,;6.67,-.77,;8,,;9.34,-.77,;9.34,-2.31,;10.67,,;10.67,1.54,;9.34,2.31,;8,1.54,;6.67,2.31,)| Show InChI InChI=1S/C16H11ClF2N2OS/c1-2-23-16-20-13-9(5-3-6-10(13)17)15(22)21(16)14-11(18)7-4-8-12(14)19/h3-8H,2H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS US Patent					Assay Description Measurement of PDE7 inhibition was carried out using a commercial phosphodiesterase activity measurement kit.Some of the compounds of the present inv...				US Patent US9796687 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MDC
					More data for this Ligand-Target Pair