BDBM351286 N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)-2- methyloctahydrocyclopenta[c]pyrrol-5- yl]methyl}oxy)-6-(methyloxy)quinazolin-4- amine::US9796704, Entry 12
SMILES: COc1cc2c(Nc3cc(Cl)c(Cl)cc3F)ncnc2cc1OC[C@@H]1C[C@H]2CN(C)C[C@H]2C1
InChI Key: InChIKey=URLSAFHMCNOLOZ-QDMKHBRRSA-N
Data: 11 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ephrin type-B receptor 4 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 2 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-B receptor 4 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-B receptor 4 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 2 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM351286 (N-(4,5-dichloro-2-fluorophenyl)-7- ({[(3aR,5s,6aS)...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
SYMPHONY EVOLUTION, INC. US Patent | Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo... | US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V | |||||||||||
More data for this Ligand-Target Pair |