BDBM351522 N-(3,4-dichlorophenyl)-7-({[2-(1- ethylpiperidin-4-yl)-1,3-thiazol-4- yl]methyl}oxy)-6-(methyloxy)quinazolin-4- amine::US9796704, Entry 242

SMILES: CCN1CCC(CC1)c1nc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)cs1

InChI Key: InChIKey=KJLBXUKNKUWCED-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 351522   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM351522 (N-(3,4-dichlorophenyl)-7-({[2-(1- ethylpiperidin-4...) Show SMILES CCN1CCC(CC1)c1nc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)cs1 Show InChI InChI=1S/C26H27Cl2N5O2S/c1-3-33-8-6-16(7-9-33)26-32-18(14-36-26)13-35-24-12-22-19(11-23(24)34-2)25(30-15-29-22)31-17-4-5-20(27)21(28)10-17/h4-5,10-12,14-16H,3,6-9,13H2,1-2H3,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM351522 (N-(3,4-dichlorophenyl)-7-({[2-(1- ethylpiperidin-4...) Show SMILES CCN1CCC(CC1)c1nc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)cs1 Show InChI InChI=1S/C26H27Cl2N5O2S/c1-3-33-8-6-16(7-9-33)26-32-18(14-36-26)13-35-24-12-22-19(11-23(24)34-2)25(30-15-29-22)31-17-4-5-20(27)21(28)10-17/h4-5,10-12,14-16H,3,6-9,13H2,1-2H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM351522 (N-(3,4-dichlorophenyl)-7-({[2-(1- ethylpiperidin-4...) Show SMILES CCN1CCC(CC1)c1nc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)cs1 Show InChI InChI=1S/C26H27Cl2N5O2S/c1-3-33-8-6-16(7-9-33)26-32-18(14-36-26)13-35-24-12-22-19(11-23(24)34-2)25(30-15-29-22)31-17-4-5-20(27)21(28)10-17/h4-5,10-12,14-16H,3,6-9,13H2,1-2H3,(H,29,30,31)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	525	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM351522 (N-(3,4-dichlorophenyl)-7-({[2-(1- ethylpiperidin-4...) Show SMILES CCN1CCC(CC1)c1nc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)cs1 Show InChI InChI=1S/C26H27Cl2N5O2S/c1-3-33-8-6-16(7-9-33)26-32-18(14-36-26)13-35-24-12-22-19(11-23(24)34-2)25(30-15-29-22)31-17-4-5-20(27)21(28)10-17/h4-5,10-12,14-16H,3,6-9,13H2,1-2H3,(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM351522 (N-(3,4-dichlorophenyl)-7-({[2-(1- ethylpiperidin-4...) Show SMILES CCN1CCC(CC1)c1nc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)cs1 Show InChI InChI=1S/C26H27Cl2N5O2S/c1-3-33-8-6-16(7-9-33)26-32-18(14-36-26)13-35-24-12-22-19(11-23(24)34-2)25(30-15-29-22)31-17-4-5-20(27)21(28)10-17/h4-5,10-12,14-16H,3,6-9,13H2,1-2H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair