BDBM351524 N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({2- [(2S)-pyrrolidin-2-yl]-1,3-thiazol-4- yl}methyl)oxy]quinazolin-4-amine::US9796704, Entry 244

SMILES: COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(n1)C1CCCN1

InChI Key: InChIKey=UJKCNZDTMJJLEP-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 351524   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM351524 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({2- [(2S)...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(n1)C1CCCN1 Show InChI InChI=1S/C23H21Cl2N5O2S/c1-31-20-8-15-19(27-12-28-22(15)29-13-4-5-16(24)17(25)7-13)9-21(20)32-10-14-11-33-23(30-14)18-3-2-6-26-18/h4-5,7-9,11-12,18,26H,2-3,6,10H2,1H3,(H,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM351524 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({2- [(2S)...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(n1)C1CCCN1 Show InChI InChI=1S/C23H21Cl2N5O2S/c1-31-20-8-15-19(27-12-28-22(15)29-13-4-5-16(24)17(25)7-13)9-21(20)32-10-14-11-33-23(30-14)18-3-2-6-26-18/h4-5,7-9,11-12,18,26H,2-3,6,10H2,1H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM351524 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({2- [(2S)...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(n1)C1CCCN1 Show InChI InChI=1S/C23H21Cl2N5O2S/c1-31-20-8-15-19(27-12-28-22(15)29-13-4-5-16(24)17(25)7-13)9-21(20)32-10-14-11-33-23(30-14)18-3-2-6-26-18/h4-5,7-9,11-12,18,26H,2-3,6,10H2,1H3,(H,27,28,29)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM351524 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({2- [(2S)...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(n1)C1CCCN1 Show InChI InChI=1S/C23H21Cl2N5O2S/c1-31-20-8-15-19(27-12-28-22(15)29-13-4-5-16(24)17(25)7-13)9-21(20)32-10-14-11-33-23(30-14)18-3-2-6-26-18/h4-5,7-9,11-12,18,26H,2-3,6,10H2,1H3,(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM351524 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({2- [(2S)...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(n1)C1CCCN1 Show InChI InChI=1S/C23H21Cl2N5O2S/c1-31-20-8-15-19(27-12-28-22(15)29-13-4-5-16(24)17(25)7-13)9-21(20)32-10-14-11-33-23(30-14)18-3-2-6-26-18/h4-5,7-9,11-12,18,26H,2-3,6,10H2,1H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair