BDBM351525 US9796704, Entry 245::[4-({[4-[(3,4-dichlorophenyl)amino]-6- (methyloxy)quinazolin-7-yl]oxy}methyl)-1,3- thiazol-2-yl]methyl benzoate

SMILES: COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1

InChI Key: InChIKey=SROSEDFOBYVYCH-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 351525   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM351525 (US9796704, Entry 245 | [4-({[4-[(3,4-dichloropheny...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1 Show InChI InChI=1S/C27H20Cl2N4O4S/c1-35-23-10-19-22(30-15-31-26(19)33-17-7-8-20(28)21(29)9-17)11-24(23)36-12-18-14-38-25(32-18)13-37-27(34)16-5-3-2-4-6-16/h2-11,14-15H,12-13H2,1H3,(H,30,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM351525 (US9796704, Entry 245 | [4-({[4-[(3,4-dichloropheny...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1 Show InChI InChI=1S/C27H20Cl2N4O4S/c1-35-23-10-19-22(30-15-31-26(19)33-17-7-8-20(28)21(29)9-17)11-24(23)36-12-18-14-38-25(32-18)13-37-27(34)16-5-3-2-4-6-16/h2-11,14-15H,12-13H2,1H3,(H,30,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM351525 (US9796704, Entry 245 | [4-({[4-[(3,4-dichloropheny...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1 Show InChI InChI=1S/C27H20Cl2N4O4S/c1-35-23-10-19-22(30-15-31-26(19)33-17-7-8-20(28)21(29)9-17)11-24(23)36-12-18-14-38-25(32-18)13-37-27(34)16-5-3-2-4-6-16/h2-11,14-15H,12-13H2,1H3,(H,30,31,33)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM351525 (US9796704, Entry 245 | [4-({[4-[(3,4-dichloropheny...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1 Show InChI InChI=1S/C27H20Cl2N4O4S/c1-35-23-10-19-22(30-15-31-26(19)33-17-7-8-20(28)21(29)9-17)11-24(23)36-12-18-14-38-25(32-18)13-37-27(34)16-5-3-2-4-6-16/h2-11,14-15H,12-13H2,1H3,(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM351525 (US9796704, Entry 245 | [4-({[4-[(3,4-dichloropheny...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1csc(COC(=O)c2ccccc2)n1 Show InChI InChI=1S/C27H20Cl2N4O4S/c1-35-23-10-19-22(30-15-31-26(19)33-17-7-8-20(28)21(29)9-17)11-24(23)36-12-18-14-38-25(32-18)13-37-27(34)16-5-3-2-4-6-16/h2-11,14-15H,12-13H2,1H3,(H,30,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair