BDBM352439 N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-c]pyridin-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl)-2-chloro-4-(4-(2-hydroxyethyl)-1H-imidazol-1-yl)benzamide (optical isomer)::US9808445, 14

SMILES: Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnc(CCO)c1

InChI Key: InChIKey=MXKIOELNJWPOBB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 352439   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor IX (Homo sapiens (Human))	BDBM352439 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnc(CCO)c1 Show InChI InChI=1S/C24H23Cl2N7O3/c25-16-7-14(32-10-13(5-6-34)29-11-32)2-3-15(16)24(35)30-20-12-1-4-18(20)33(9-12)23-21-19(17(26)8-28-23)22(27)31-36-21/h2-3,7-8,10-12,18,20,34H,1,4-6,9H2,(H2,27,31)(H,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair