Found 2 hits for monomerid = 354661 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM354661
(US9809582, Example 3)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CN2CCC(CC2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,wD:38.40,(-6.45,-9.72,;-5.11,-10.49,;-3.78,-9.72,;-2.44,-10.49,;-1.11,-9.72,;-1.11,-8.18,;-2.44,-7.41,;-3.78,-8.18,;-5.11,-7.41,;-6.45,-8.18,;.22,-7.41,;1.56,-8.18,;2.89,-7.41,;2.89,-5.87,;1.56,-5.1,;4.22,-5.1,;5.56,-5.87,;6.89,-5.1,;5.56,-7.41,;4.22,-8.18,;4.22,-9.72,;.22,-5.87,;-1.11,-5.1,;-2.44,-5.87,;-1.11,-3.56,;-2.36,-2.66,;-1.88,-1.19,;-.34,-1.19,;.43,.14,;-.34,1.48,;.43,2.81,;-.34,4.14,;-1.88,4.14,;-2.65,2.81,;-1.88,1.48,;-1.48,5.63,;-2.57,6.72,;.01,6.03,;.4,7.52,;1.89,7.92,;2.29,9.4,;1.2,10.49,;-.29,10.09,;-.69,8.61,;.8,8.21,;.8,9.75,;-3.37,4.54,;-3.77,6.03,;-5.25,6.43,;-6.34,5.34,;-5.94,3.85,;-4.46,3.45,;.13,-2.66,)| Show InChI InChI=1S/C40H43Cl2N3O7S/c1-49-33-10-8-27(20-35(33)50-2)34(21-30-31(41)23-45(48)24-32(30)42)51-38(46)37-11-9-29(53-37)22-44-18-14-40(15-19-44,28-6-4-3-5-7-28)39(47)52-36-25-43-16-12-26(36)13-17-43/h3-11,20,23-24,26,34,36H,12-19,21-22,25H2,1-2H3/t34-,36-/m0/s1 | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIESI FARMACEUTICI S.p.A.
US Patent
| Assay Description
PDE4B2 activity is detected using the LANCE Ultra cAMP homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay from Perkin E... |
US Patent US9809582 (2017)
BindingDB Entry DOI: 10.7270/Q2H1345N |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM354661
(US9809582, Example 3)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CN2CCC(CC2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,wD:38.40,(-6.45,-9.72,;-5.11,-10.49,;-3.78,-9.72,;-2.44,-10.49,;-1.11,-9.72,;-1.11,-8.18,;-2.44,-7.41,;-3.78,-8.18,;-5.11,-7.41,;-6.45,-8.18,;.22,-7.41,;1.56,-8.18,;2.89,-7.41,;2.89,-5.87,;1.56,-5.1,;4.22,-5.1,;5.56,-5.87,;6.89,-5.1,;5.56,-7.41,;4.22,-8.18,;4.22,-9.72,;.22,-5.87,;-1.11,-5.1,;-2.44,-5.87,;-1.11,-3.56,;-2.36,-2.66,;-1.88,-1.19,;-.34,-1.19,;.43,.14,;-.34,1.48,;.43,2.81,;-.34,4.14,;-1.88,4.14,;-2.65,2.81,;-1.88,1.48,;-1.48,5.63,;-2.57,6.72,;.01,6.03,;.4,7.52,;1.89,7.92,;2.29,9.4,;1.2,10.49,;-.29,10.09,;-.69,8.61,;.8,8.21,;.8,9.75,;-3.37,4.54,;-3.77,6.03,;-5.25,6.43,;-6.34,5.34,;-5.94,3.85,;-4.46,3.45,;.13,-2.66,)| Show InChI InChI=1S/C40H43Cl2N3O7S/c1-49-33-10-8-27(20-35(33)50-2)34(21-30-31(41)23-45(48)24-32(30)42)51-38(46)37-11-9-29(53-37)22-44-18-14-40(15-19-44,28-6-4-3-5-7-28)39(47)52-36-25-43-16-12-26(36)13-17-43/h3-11,20,23-24,26,34,36H,12-19,21-22,25H2,1-2H3/t34-,36-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIESI FARMACEUTICI S.p.A.
US Patent
| Assay Description
Human M3 receptor membranes (15 μg/well) from Perkin Elmer are incubated with 0.52 nM Scopolamine Methyl Chloride, [N-methyl-3H] with or without... |
US Patent US9809582 (2017)
BindingDB Entry DOI: 10.7270/Q2H1345N |
More data for this
Ligand-Target Pair | |
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