BDBM354744 Preparation of 5,5′-(1H-pyrrolo[2,3-b]pyridine-3,5-diyl)bis(N,N-dimethylpyridin-2-amine) ::US10485800, Example 21::US9814704, Example 21

SMILES: CN(C)c1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1ccc(nc1)N(C)C

InChI Key: InChIKey=REVMLCZGWSFWGN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354744   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354744 (Preparation of 5,5′-(1H-pyrrolo[2,3-b]pyridi...) Show SMILES CN(C)c1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1ccc(nc1)N(C)C Show InChI InChI=1S/C21H22N6/c1-26(2)19-7-5-14(10-22-19)16-9-17-18(13-25-21(17)24-12-16)15-6-8-20(23-11-15)27(3)4/h5-13H,1-4H3,(H,24,25)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354744 (Preparation of 5,5′-(1H-pyrrolo[2,3-b]pyridi...) Show SMILES CN(C)c1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1ccc(nc1)N(C)C Show InChI InChI=1S/C21H22N6/c1-26(2)19-7-5-14(10-22-19)16-9-17-18(13-25-21(17)24-12-16)15-6-8-20(23-11-15)27(3)4/h5-13H,1-4H3,(H,24,25)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair