BDBM354745 Preparation of 5-(3-(3-chloro-4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N,N-dimethylpyridin-2-amine ::US10485800, Example 22::US9814704, Example 22

SMILES: CN(C)c1ccc(cn1)-c1cnc2[nH]cc(-c3ccc(F)c(Cl)c3)c2c1

InChI Key: InChIKey=QTKBXPVTDMTPMZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354745   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354745 (Preparation of 5-(3-(3-chloro-4-fluorophenyl)-1H-p...) Show SMILES CN(C)c1ccc(cn1)-c1cnc2[nH]cc(-c3ccc(F)c(Cl)c3)c2c1 Show InChI InChI=1S/C20H16ClFN4/c1-26(2)19-6-4-13(9-23-19)14-7-15-16(11-25-20(15)24-10-14)12-3-5-18(22)17(21)8-12/h3-11H,1-2H3,(H,24,25)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354745 (Preparation of 5-(3-(3-chloro-4-fluorophenyl)-1H-p...) Show SMILES CN(C)c1ccc(cn1)-c1cnc2[nH]cc(-c3ccc(F)c(Cl)c3)c2c1 Show InChI InChI=1S/C20H16ClFN4/c1-26(2)19-6-4-13(9-23-19)14-7-15-16(11-25-20(15)24-10-14)12-3-5-18(22)17(21)8-12/h3-11H,1-2H3,(H,24,25)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair