BDBM354771 6-(3,5-dichlorophenyl)-1- (1H-indol-5-yl)-1H- imidazo[4,5-b]pyrazin- 2(3H)-one::US10485800, Example 48::US9814704, Example 48

SMILES: Clc1cc(Cl)cc(c1)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1

InChI Key: InChIKey=YIRDNPKYRANUCH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354771   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354771 (6-(3,5-dichlorophenyl)-1- (1H-indol-5-yl)-1H- imid...) Show SMILES Clc1cc(Cl)cc(c1)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1 Show InChI InChI=1S/C19H11Cl2N5O/c20-12-5-11(6-13(21)8-12)16-9-23-17-18(24-16)26(19(27)25-17)14-1-2-15-10(7-14)3-4-22-15/h1-9,22H,(H,23,25,27)	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354771 (6-(3,5-dichlorophenyl)-1- (1H-indol-5-yl)-1H- imid...) Show SMILES Clc1cc(Cl)cc(c1)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1 Show InChI InChI=1S/C19H11Cl2N5O/c20-12-5-11(6-13(21)8-12)16-9-23-17-18(24-16)26(19(27)25-17)14-1-2-15-10(7-14)3-4-22-15/h1-9,22H,(H,23,25,27)	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair