BDBM354789 1-(1H-indol-5-yl)-6-(2-(4- methylpiperazin-1- yl)pyridin-4-yl)-1H- imidazo[4,5-b]pyrazin- 2(3H)-one::US10485800, Example 66::US9814704, Example 66

SMILES: CN1CCN(CC1)c1cc(ccn1)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1

InChI Key: InChIKey=YIUDJPYFKOHYHD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354789   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354789 (1-(1H-indol-5-yl)-6-(2-(4- methylpiperazin-1- yl)p...) Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1 Show InChI InChI=1S/C23H22N8O/c1-29-8-10-30(11-9-29)20-13-16(5-7-25-20)19-14-26-21-22(27-19)31(23(32)28-21)17-2-3-18-15(12-17)4-6-24-18/h2-7,12-14,24H,8-11H2,1H3,(H,26,28,32)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354789 (1-(1H-indol-5-yl)-6-(2-(4- methylpiperazin-1- yl)p...) Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1 Show InChI InChI=1S/C23H22N8O/c1-29-8-10-30(11-9-29)20-13-16(5-7-25-20)19-14-26-21-22(27-19)31(23(32)28-21)17-2-3-18-15(12-17)4-6-24-18/h2-7,12-14,24H,8-11H2,1H3,(H,26,28,32)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair