BDBM354798 1-cyclopentyl-6-(3,4- dimethoxyphenyl)-1H- imidazo[4,5-b]pyrazin- 2(3H)-one::US10485800, Example 75::US9814704, Example 75

SMILES: COc1ccc(cc1OC)-c1cnc2[nH]c(=O)n(C3CCCC3)c2n1

InChI Key: InChIKey=JYRONAVVWQIHMW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354798   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354798 (1-cyclopentyl-6-(3,4- dimethoxyphenyl)-1H- imidazo...) Show SMILES COc1ccc(cc1OC)-c1cnc2[nH]c(=O)n(C3CCCC3)c2n1 Show InChI InChI=1S/C18H20N4O3/c1-24-14-8-7-11(9-15(14)25-2)13-10-19-16-17(20-13)22(18(23)21-16)12-5-3-4-6-12/h7-10,12H,3-6H2,1-2H3,(H,19,21,23)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354798 (1-cyclopentyl-6-(3,4- dimethoxyphenyl)-1H- imidazo...) Show SMILES COc1ccc(cc1OC)-c1cnc2[nH]c(=O)n(C3CCCC3)c2n1 Show InChI InChI=1S/C18H20N4O3/c1-24-14-8-7-11(9-15(14)25-2)13-10-19-16-17(20-13)22(18(23)21-16)12-5-3-4-6-12/h7-10,12H,3-6H2,1-2H3,(H,19,21,23)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair