BDBM354827 1-(1H-benzo[d]imidazol-5- yl)-6-(4- morpholinophenyl)-1H- imidazo[4,5-b]pyrazin- 2(3H)-one::US10485800, Example 104::US9814704, Example 104

SMILES: O=c1[nH]c2ncc(nc2n1-c1ccc2[nH]cnc2c1)-c1ccc(cc1)N1CCOCC1

InChI Key: InChIKey=DPSOLRXJTWBTBL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354827   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354827 (1-(1H-benzo[d]imidazol-5- yl)-6-(4- morpholinophen...) Show SMILES O=c1[nH]c2ncc(nc2n1-c1ccc2[nH]cnc2c1)-c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C22H19N7O2/c30-22-27-20-21(29(22)16-5-6-17-18(11-16)25-13-24-17)26-19(12-23-20)14-1-3-15(4-2-14)28-7-9-31-10-8-28/h1-6,11-13H,7-10H2,(H,24,25)(H,23,27,30)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354827 (1-(1H-benzo[d]imidazol-5- yl)-6-(4- morpholinophen...) Show SMILES O=c1[nH]c2ncc(nc2n1-c1ccc2[nH]cnc2c1)-c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C22H19N7O2/c30-22-27-20-21(29(22)16-5-6-17-18(11-16)25-13-24-17)26-19(12-23-20)14-1-3-15(4-2-14)28-7-9-31-10-8-28/h1-6,11-13H,7-10H2,(H,24,25)(H,23,27,30)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair