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SMILES: COC(C)(C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12

InChI Key: InChIKey=PINGLSOLCPNZHX-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355891   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]


(Homo sapiens (Human))		BDBM355891
PNG
(1-(2-chloro-7-(2- methoxypropan-2- yl)pyrazolo[1,5...)
Show SMILES COC(C)(C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H16ClF3N6O2/c1-16(2,29-3)14-10(8-23-13-7-12(18)26-27(13)14)25-15(28)24-9-4-5-22-11(6-9)17(19,20)21/h4-8H,1-3H3,(H2,22,24,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...

US Patent US10442808 (2019)


BindingDB Entry DOI: 10.7270/Q2S75JQ3
More data for this
Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM355891
PNG
(1-(2-chloro-7-(2- methoxypropan-2- yl)pyrazolo[1,5...)
Show SMILES COC(C)(C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
Show InChI InChI=1S/C17H16ClF3N6O2/c1-16(2,29-3)14-10(8-23-13-7-12(18)26-27(13)14)25-15(28)24-9-4-5-22-11(6-9)17(19,20)21/h4-8H,1-3H3,(H2,22,24,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.00500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...

US Patent US9815842 (2017)


BindingDB Entry DOI: 10.7270/Q24F1T0N
More data for this
Ligand-Target Pair