BDBM35598 pyrazolo pyrimidine, 5c

SMILES: Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)c3ccccc3)c2n1

InChI Key: InChIKey=AOIQRIAWTIYQBH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35598   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110α/p85α (Homo sapiens (Human))	BDBM35598 (pyrazolo pyrimidine, 5c) Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)c3ccccc3)c2n1 Show InChI InChI=1S/C27H28N6O3/c34-22-8-4-7-20(17-22)24-29-25(31-13-15-36-16-14-31)23-18-28-33(26(23)30-24)21-9-11-32(12-10-21)27(35)19-5-2-1-3-6-19/h1-8,17-18,21,34H,9-16H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	25
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 52: 7081-9 (2009) Article DOI: 10.1021/jm9012642 BindingDB Entry DOI: 10.7270/Q2NS0S73
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM35598 (pyrazolo pyrimidine, 5c) Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)c3ccccc3)c2n1 Show InChI InChI=1S/C27H28N6O3/c34-22-8-4-7-20(17-22)24-29-25(31-13-15-36-16-14-31)23-18-28-33(26(23)30-24)21-9-11-32(12-10-21)27(35)19-5-2-1-3-6-19/h1-8,17-18,21,34H,9-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	23
Wyeth Research					Assay Description The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...				J Med Chem 52: 7081-9 (2009) Article DOI: 10.1021/jm9012642 BindingDB Entry DOI: 10.7270/Q2NS0S73
					More data for this Ligand-Target Pair