Found 5 hits for monomerid = 35600 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35600
(pyrazolo pyrimidine, 5e)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-4-7-21(17-23)25-29-26(32-13-15-35-16-14-32)24-18-28-33(27(24)30-25)22-9-11-31(12-10-22)19-20-5-2-1-3-6-20/h1-8,17-18,22,34H,9-16,19H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642 BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this Ligand-Target Pair | |
p110α/p85α
(Homo sapiens (Human)) | BDBM35600
(pyrazolo pyrimidine, 5e)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-4-7-21(17-23)25-29-26(32-13-15-35-16-14-32)24-18-28-33(27(24)30-25)22-9-11-31(12-10-22)19-20-5-2-1-3-6-20/h1-8,17-18,22,34H,9-16,19H2 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642 BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35600
(pyrazolo pyrimidine, 5e)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-4-7-21(17-23)25-29-26(32-13-15-35-16-14-32)24-18-28-33(27(24)30-25)22-9-11-31(12-10-22)19-20-5-2-1-3-6-20/h1-8,17-18,22,34H,9-16,19H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human TOR in HEK293 cells by DELFIA |
Bioorg Med Chem Lett 20: 636-9 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.051 BindingDB Entry DOI: 10.7270/Q2V98852 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM35600
(pyrazolo pyrimidine, 5e)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-4-7-21(17-23)25-29-26(32-13-15-35-16-14-32)24-18-28-33(27(24)30-25)22-9-11-31(12-10-22)19-20-5-2-1-3-6-20/h1-8,17-18,22,34H,9-16,19H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of GST-GRP1-fused PI3Kgamma by microtiter plate based fluorescence polarization assay |
Bioorg Med Chem Lett 20: 636-9 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.051 BindingDB Entry DOI: 10.7270/Q2V98852 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35600
(pyrazolo pyrimidine, 5e)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-4-7-21(17-23)25-29-26(32-13-15-35-16-14-32)24-18-28-33(27(24)30-25)22-9-11-31(12-10-22)19-20-5-2-1-3-6-20/h1-8,17-18,22,34H,9-16,19H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of GST-GRP1-fused PI3Kalpha by microtiter plate based fluorescence polarization assay |
Bioorg Med Chem Lett 20: 636-9 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.051 BindingDB Entry DOI: 10.7270/Q2V98852 |
More data for this Ligand-Target Pair | |