BDBM356072 (S)-2-fluoro-N-(6-((2-hydroxy- N-methylpropanamido)methyl)- 2-phenylpyridin-3-yl)-5-(1- methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 72

SMILES: C[C@H](O)C(=O)N(C)Cc1ccc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)c(n1)-c1ccccc1

InChI Key: InChIKey=LNUPWVBVUZCQNU-INIZCTEOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356072   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356072 ((S)-2-fluoro-N-(6-((2-hydroxy- N-methylpropanamido...) Show SMILES C[C@H](O)C(=O)N(C)Cc1ccc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)c(n1)-c1ccccc1 |r| Show InChI InChI=1S/C28H25F4N5O3/c1-16(38)27(40)36(2)15-18-9-10-24(25(33-18)17-7-5-4-6-8-17)34-26(39)20-13-19(23-11-12-37(3)35-23)21(14-22(20)29)28(30,31)32/h4-14,16,38H,15H2,1-3H3,(H,34,39)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair