BDBM356161 2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(5-oxo-2- phenyl-6,7-dihydro-5H- pyrrolo[3,4-b]pyridin-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 161

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cc3C(=O)NCc3nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=WQRLTGYCXGUULM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356161   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356161 (2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(5-oxo-2-...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc3C(=O)NCc3nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C25H17F4N5O2/c1-34-8-7-19(33-34)14-9-15(18(26)11-17(14)25(27,28)29)24(36)32-20-10-16-21(12-30-23(16)35)31-22(20)13-5-3-2-4-6-13/h2-11H,12H2,1H3,(H,30,35)(H,32,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair