BDBM356168 2-fluoro-N-(5-(hydroxymethyl)- 6'-phenyl-[2,3'-bipyridin]-5'-yl)- 5-(pyrimidin-2-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 168

SMILES: OCc1ccc(nc1)-c1cnc(c(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)c1)-c1ccccc1

InChI Key: InChIKey=DZAHOTGVPUBAGB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356168   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356168 (2-fluoro-N-(5-(hydroxymethyl)- 6'-phenyl-[2,3'-bip...) Show SMILES OCc1ccc(nc1)-c1cnc(c(NC(=O)c2cc(-c3ncccn3)c(cc2F)C(F)(F)F)c1)-c1ccccc1 Show InChI InChI=1S/C29H19F4N5O2/c30-23-13-22(29(31,32)33)20(27-34-9-4-10-35-27)12-21(23)28(40)38-25-11-19(24-8-7-17(16-39)14-36-24)15-37-26(25)18-5-2-1-3-6-18/h1-15,39H,16H2,(H,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair