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SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cc(cnc2-c2ccccc2)-c2ccc(cn2)C(C)(C)O)c(F)cc1C(F)(F)F

InChI Key: InChIKey=QVEREYMZYJNVPY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356172   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM356172
PNG
(2-fluoro-N-(5-(2- hydroxypropan-2-yl)-6'-phenyl- [...)
Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(cnc2-c2ccccc2)-c2ccc(cn2)C(C)(C)O)c(F)cc1C(F)(F)F
Show InChI InChI=1S/C31H25F4N5O2/c1-30(2,42)20-9-10-25(36-17-20)19-13-27(28(37-16-19)18-7-5-4-6-8-18)38-29(41)22-14-21(26-11-12-40(3)39-26)23(15-24(22)32)31(33,34)35/h4-17,42H,1-3H3,(H,38,41)
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.260n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...

US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair