BDBM356634 1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- fluoropiperidin-2- one::US10214507, Compound 70::US10759777, Compound 70

SMILES: OC(CN1CCCC(F)C1=O)Cn1c2ccccc2c2ccccc12

InChI Key: InChIKey=HITFQOTWDGNWFR-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 356634   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Period circadian protein homolog 2 (Homo sapiens (Human))	BDBM356634 (1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- fluo...) Show SMILES OC(CN1CCCC(F)C1=O)Cn1c2ccccc2c2ccccc12 Show InChI InChI=1S/C20H21FN2O2/c21-17-8-5-11-22(20(17)25)12-14(24)13-23-18-9-3-1-6-15(18)16-7-2-4-10-19(16)23/h1-4,6-7,9-10,14,17,24H,5,8,11-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
Synchronicity Pharma, Inc. US Patent					Assay Description In brief, stable U20S reporter cells harboring Per2-dLuc were plated at a density of 30,000 cells/well in Corning 96-well, solid white, flat bottom, ...				US Patent US10759777 (2020)
					More data for this Ligand-Target Pair
Period circadian protein homolog 2 (Homo sapiens (Human))	BDBM356634 (1-(3-(9H-carbazol- 9-yl)-2- hydroxypropyl)-3- fluo...) Show SMILES OC(CN1CCCC(F)C1=O)Cn1c2ccccc2c2ccccc12 Show InChI InChI=1S/C20H21FN2O2/c21-17-8-5-11-22(20(17)25)12-14(24)13-23-18-9-3-1-6-15(18)16-7-2-4-10-19(16)23/h1-4,6-7,9-10,14,17,24H,5,8,11-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
Reset Therapeutics, Inc. US Patent					Assay Description Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...				US Patent US10214507 (2019) BindingDB Entry DOI: 10.7270/Q2KH0QMT
					More data for this Ligand-Target Pair