BindingDB PrimarySearch

BDBM356940 (S)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- hydroxypropyl)-3- fluoropyrrolidin-2- one::US10214507, Compound 120::US10759777, Compound 120

SMILES: O[C@@H](CN1CC[C@H](F)C1=O)Cn1c2ccc(F)cc2c2cc(F)ccc12

InChI Key: InChIKey=CTLHGLZELHMPOK-BBRMVZONSA-N

Data: 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 356940
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Period circadian protein homolog 2 (Homo sapiens (Human))	BDBM356940 ((S)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	302	n/a	n/a	n/a	n/a
Synchronicity Pharma, Inc. US Patent					Assay Description In brief, stable U20S reporter cells harboring Per2-dLuc were plated at a density of 30,000 cells/well in Corning 96-well, solid white, flat bottom, ...				US Patent US10759777 (2020)
Synchronicity Pharma, Inc. US Patent					More data for this Ligand-Target Pair
Period circadian protein homolog 2 (Homo sapiens (Human))	BDBM356940 ((S)-1-((R)-3-(3,6- difluoro-9H- carbazol-9-yl)-2- ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	302	n/a	n/a	n/a	n/a
Reset Therapeutics, Inc. US Patent					Assay Description Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...				US Patent US10214507 (2019) BindingDB Entry DOI: 10.7270/Q2KH0QMT
Reset Therapeutics, Inc. US Patent					More data for this Ligand-Target Pair