BDBM357655 7-(3-(4- fluorophenoxy) benzyl)-3H- [1,2,3]triazolo [4,5-b]pyridin- 5-amine::US10214527, Example 27

SMILES: Nc1cc(Cc2cccc(Oc3ccc(F)cc3)c2)c2nn[nH]c2n1

InChI Key: InChIKey=UBLZYADWXYLASG-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 357655   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Myeloperoxidase (Homo sapiens (Human))	BDBM357655 (7-(3-(4- fluorophenoxy) benzyl)-3H- [1,2,3]triazol...) Show SMILES Nc1cc(Cc2cccc(Oc3ccc(F)cc3)c2)c2nn[nH]c2n1 Show InChI InChI=1S/C18H14FN5O/c19-13-4-6-14(7-5-13)25-15-3-1-2-11(9-15)8-12-10-16(20)21-18-17(12)22-24-23-18/h1-7,9-10H,8H2,(H3,20,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog # A12222) which...				US Patent US10214527 (2019) BindingDB Entry DOI: 10.7270/Q2DR2XRQ
					More data for this Ligand-Target Pair