null

SMILES: Cc1ccn(CCC(=O)N2CCN(C(=O)C2(C)C)c2cc(ccc2C#N)-c2cc(Cl)c3c(N)ncnn23)n1

InChI Key: InChIKey=SSUIICBDLSZQSI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358665   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM358665 (4-(4-amino-5-chloropyrrolo[2,1-f] [1,2,4]triazin-7...) Show SMILES Cc1ccn(CCC(=O)N2CCN(C(=O)C2(C)C)c2cc(ccc2C#N)-c2cc(Cl)c3c(N)ncnn23)n1 Show InChI InChI=1S/C26H26ClN9O2/c1-16-6-8-33(32-16)9-7-22(37)35-11-10-34(25(38)26(35,2)3)20-12-17(4-5-18(20)14-28)21-13-19(27)23-24(29)30-15-31-36(21)23/h4-6,8,12-13,15H,7,9-11H2,1-3H3,(H2,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...				US Patent US10214537 (2019) BindingDB Entry DOI: 10.7270/Q2HH6NB2
					More data for this Ligand-Target Pair