null
SMILES: CCc1nc(cs1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC
InChI Key: InChIKey=IAMKUFQDLHWRPW-PMACEKPBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor-type tyrosine-protein phosphatase beta (Homo sapiens (Human)) | BDBM359118 (US10220048, Compound AA28 | US10952992, No. AA28 |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC. US Patent | Assay Description HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N... | US Patent US10220048 (2019) BindingDB Entry DOI: 10.7270/Q2VT1VC9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein phosphatase beta (Homo sapiens (Human)) | BDBM359118 (US10220048, Compound AA28 | US10952992, No. AA28 |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein phosphatase beta (Homo sapiens (Human)) | BDBM359118 (US10220048, Compound AA28 | US10952992, No. AA28 |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO PHARMACEUTICALS, INC. US Patent | Assay Description Non-limiting examples of the HPTP-β IC50 (μM) activity. | US Patent US10952992 (2021) | |||||||||||
More data for this Ligand-Target Pair |