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SMILES: COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)C[C@H](O)c2ccc(Cl)cc2)n1-c1c(OC)cccc1OC

InChI Key: InChIKey=NLLSIYDQJLSOLX-QHCPKHFHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 359969   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM359969 ((2R)-2-(4-chlorophenyl)-N-(4-(2,6-dimethoxyphenyl)...) Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)C[C@H](O)c2ccc(Cl)cc2)n1-c1c(OC)cccc1OC |r,wU:23.24,(-8.84,1.66,;-9.16,3.16,;-8.02,4.19,;-8.34,5.7,;-7.19,6.73,;-5.73,6.25,;-5.41,4.75,;-6.55,3.72,;-3.94,4.27,;-3.47,2.81,;-1.93,2.81,;-1.45,4.27,;.01,4.75,;.33,6.25,;1.87,6.42,;2.49,7.83,;4.02,8,;1.58,9.07,;3.11,9.24,;1.16,3.72,;1.56,2.23,;.07,2.63,;2.49,4.49,;3.83,3.72,;3.83,2.18,;5.16,4.49,;6.49,3.72,;7.83,4.49,;7.83,6.03,;9.16,6.8,;6.49,6.8,;5.16,6.03,;-2.7,5.18,;-2.7,6.72,;-4.03,7.49,;-5.36,6.72,;-6.7,7.49,;-4.03,9.03,;-2.7,9.8,;-1.36,9.03,;-1.36,7.49,;-.03,6.72,;1.3,7.49,)| Show InChI InChI=1S/C29H36ClN5O6SSi/c1-39-24-10-8-11-25(40-2)27(24)35-28(22-9-7-12-26(31-22)41-3)32-33-29(35)34(17-18-43(4,5)6)42(37,38)19-23(36)20-13-15-21(30)16-14-20/h7-16,23,36H,17-19H2,1-6H3/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.340	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US9845310 (2017) BindingDB Entry DOI: 10.7270/Q28P62TV
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM359969 ((2R)-2-(4-chlorophenyl)-N-(4-(2,6-dimethoxyphenyl)...) Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)C[C@H](O)c2ccc(Cl)cc2)n1-c1c(OC)cccc1OC |r,wU:23.24,(-8.84,1.66,;-9.16,3.16,;-8.02,4.19,;-8.34,5.7,;-7.19,6.73,;-5.73,6.25,;-5.41,4.75,;-6.55,3.72,;-3.94,4.27,;-3.47,2.81,;-1.93,2.81,;-1.45,4.27,;.01,4.75,;.33,6.25,;1.87,6.42,;2.49,7.83,;4.02,8,;1.58,9.07,;3.11,9.24,;1.16,3.72,;1.56,2.23,;.07,2.63,;2.49,4.49,;3.83,3.72,;3.83,2.18,;5.16,4.49,;6.49,3.72,;7.83,4.49,;7.83,6.03,;9.16,6.8,;6.49,6.8,;5.16,6.03,;-2.7,5.18,;-2.7,6.72,;-4.03,7.49,;-5.36,6.72,;-6.7,7.49,;-4.03,9.03,;-2.7,9.8,;-1.36,9.03,;-1.36,7.49,;-.03,6.72,;1.3,7.49,)| Show InChI InChI=1S/C29H36ClN5O6SSi/c1-39-24-10-8-11-25(40-2)27(24)35-28(22-9-7-12-26(31-22)41-3)32-33-29(35)34(17-18-43(4,5)6)42(37,38)19-23(36)20-13-15-21(30)16-14-20/h7-16,23,36H,17-19H2,1-6H3/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.340	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair