BDBM360002 (1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-::US10221162, Example 297.0::US10221162, Example 298.0::US10221162, Example 299.0::US10221162, Example 300.0::US10221162, Example 301.0::US10221162, Example 303.0

SMILES: CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1

InChI Key: InChIKey=LVTQOZKWKDGPMC-VGSWGCGISA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 360002   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM360002 ((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| Show InChI InChI=1S/C25H30N6O5S2/c1-14-11-18(13-26-12-14)23-28-29-25(31(23)21-19(34-5)9-8-10-20(21)35-6)30-38(32,33)17(4)22(36-7)24-27-15(2)16(3)37-24/h8-13,17,22H,1-7H3,(H,29,30)/t17-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM360002 ((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| Show InChI InChI=1S/C25H30N6O5S2/c1-14-11-18(13-26-12-14)23-28-29-25(31(23)21-19(34-5)9-8-10-20(21)35-6)30-38(32,33)17(4)22(36-7)24-27-15(2)16(3)37-24/h8-13,17,22H,1-7H3,(H,29,30)/t17-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM360002 ((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| Show InChI InChI=1S/C25H30N6O5S2/c1-14-11-18(13-26-12-14)23-28-29-25(31(23)21-19(34-5)9-8-10-20(21)35-6)30-38(32,33)17(4)22(36-7)24-27-15(2)16(3)37-24/h8-13,17,22H,1-7H3,(H,29,30)/t17-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.30	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM360002 ((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| Show InChI InChI=1S/C25H30N6O5S2/c1-14-11-18(13-26-12-14)23-28-29-25(31(23)21-19(34-5)9-8-10-20(21)35-6)30-38(32,33)17(4)22(36-7)24-27-15(2)16(3)37-24/h8-13,17,22H,1-7H3,(H,29,30)/t17-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM360002 ((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| Show InChI InChI=1S/C25H30N6O5S2/c1-14-11-18(13-26-12-14)23-28-29-25(31(23)21-19(34-5)9-8-10-20(21)35-6)30-38(32,33)17(4)22(36-7)24-27-15(2)16(3)37-24/h8-13,17,22H,1-7H3,(H,29,30)/t17-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	78	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM360002 ((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...) Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| Show InChI InChI=1S/C25H30N6O5S2/c1-14-11-18(13-26-12-14)23-28-29-25(31(23)21-19(34-5)9-8-10-20(21)35-6)30-38(32,33)17(4)22(36-7)24-27-15(2)16(3)37-24/h8-13,17,22H,1-7H3,(H,29,30)/t17-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.680	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10221162 (2019) BindingDB Entry DOI: 10.7270/Q2ZK5JXS
					More data for this Ligand-Target Pair