BDBM361076 (R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sulfamoyl-3-(2H-tetrazol-5-yl)phenyl)sulfonamido)-1,1-dimethylpyrrolidin-1-ium chloride::US10221163, Example 233::US10544130, Example 233
SMILES: C[N]1(C)CC[C@H](C1)NS(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O
InChI Key: InChIKey=YMBSYOSFIYTLEM-GXZRWPEMSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metallo-beta-lactamase type 2 (Serratia marcescens) | BDBM361076 ((R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sul...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.305 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | US Patent US10221163 (2019) BindingDB Entry DOI: 10.7270/Q2RX9FB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase NDM-1 (Klebsiella pneumoniae) | BDBM361076 ((R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sul...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0230 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | US Patent US10221163 (2019) BindingDB Entry DOI: 10.7270/Q2RX9FB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase () | BDBM361076 ((R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sul...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | US Patent US10544130 (2020) BindingDB Entry DOI: 10.7270/Q2C82CQH | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metallo-beta-lactamase type 2 (Serratia marcescens) | BDBM361076 ((R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sul...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.305 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | US Patent US10544130 (2020) BindingDB Entry DOI: 10.7270/Q2C82CQH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase NDM-1 (Klebsiella pneumoniae) | BDBM361076 ((R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sul...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0230 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | US Patent US10544130 (2020) BindingDB Entry DOI: 10.7270/Q2C82CQH | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase VIM-1 (Klebsiella pneumoniae) | BDBM361076 ((R)-3-((4-(2-amino-1H-benzo[d]imidazol-4-yl)-2-sul...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | US Patent US10221163 (2019) BindingDB Entry DOI: 10.7270/Q2RX9FB1 | |||||||||||
More data for this Ligand-Target Pair |