BDBM361077 (R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 234::US10544130, Example 234

SMILES: Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1

InChI Key: InChIKey=OKNVYQOHMDWUOT-HNLKAFMCSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361077   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metallo-beta-lactamase type 2 (Serratia marcescens)	BDBM361077 ((R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1...) Show SMILES Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r| Show InChI InChI=1S/C18H17IN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US10221163 (2019) BindingDB Entry DOI: 10.7270/Q2RX9FB1
					More data for this Ligand-Target Pair
Beta-lactamase NDM-1 (Klebsiella pneumoniae)	BDBM361077 ((R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1...) Show SMILES Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r| Show InChI InChI=1S/C18H17IN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US10221163 (2019) BindingDB Entry DOI: 10.7270/Q2RX9FB1
					More data for this Ligand-Target Pair
Beta-lactamase ()	BDBM361077 ((R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1...) Show SMILES Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r| Show InChI InChI=1S/C18H17IN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0830	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent									US Patent US10544130 (2020) BindingDB Entry DOI: 10.7270/Q2C82CQH
					More data for this Ligand-Target Pair
Metallo-beta-lactamase type 2 (Serratia marcescens)	BDBM361077 ((R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1...) Show SMILES Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r| Show InChI InChI=1S/C18H17IN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US10544130 (2020) BindingDB Entry DOI: 10.7270/Q2C82CQH
					More data for this Ligand-Target Pair
Beta-lactamase NDM-1 (Klebsiella pneumoniae)	BDBM361077 ((R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1...) Show SMILES Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r| Show InChI InChI=1S/C18H17IN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent									US Patent US10544130 (2020) BindingDB Entry DOI: 10.7270/Q2C82CQH
					More data for this Ligand-Target Pair
Beta-lactamase VIM-1 (Klebsiella pneumoniae)	BDBM361077 ((R)-4-(2-amino-6-iodo-1H-benzo[d]imidazol-4-yl)-N1...) Show SMILES Nc1nc2c(cc(I)cc2[nH]1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r| Show InChI InChI=1S/C18H17IN10O4S2/c19-8-5-11(15-12(6-8)23-18(20)24-15)10-1-2-13(35(32,33)27-9-3-4-22-7-9)16(34(21,30)31)14(10)17-25-28-29-26-17/h1-2,5-6,9,22,27H,3-4,7H2,(H2,20,23)(H2,21,30,31)/b11-10+/t9-/m1/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0830	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US10221163 (2019) BindingDB Entry DOI: 10.7270/Q2RX9FB1
					More data for this Ligand-Target Pair