BDBM362178 US10272077, Example 8 from U.S. Pat. No. 7,390,798::US9833448, Example 8 from U.S. Pat. No. 7,390,798

SMILES: CN1C[C@@H](CC[C@@H](NC(=O)c2ccc3CC4(Cc3c2)C(=O)Nc2ncccc42)C1=O)c1cccc(F)c1F

InChI Key: InChIKey=BZPVIHOWUYCVHT-HZWJCNPPSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362178   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CGRP type 1 receptor (Homo sapiens (Human))	BDBM362178 (US10272077, Example 8 from U.S. Pat. No. 7,390,798...) Show SMILES CN1C[C@@H](CC[C@@H](NC(=O)c2ccc3CC4(Cc3c2)C(=O)Nc2ncccc42)C1=O)c1cccc(F)c1F |r| Show InChI InChI=1S/C29H26F2N4O3/c1-35-15-18(20-4-2-6-22(30)24(20)31)9-10-23(27(35)37)33-26(36)16-7-8-17-13-29(14-19(17)12-16)21-5-3-11-32-25(21)34-28(29)38/h2-8,11-12,18,23H,9-10,13-15H2,1H3,(H,33,36)(H,32,34,38)/t18-,23-,29?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q25X2C8C
					More data for this Ligand-Target Pair
CGRP type 1 receptor (Homo sapiens (Human))	BDBM362178 (US10272077, Example 8 from U.S. Pat. No. 7,390,798...) Show SMILES CN1C[C@@H](CC[C@@H](NC(=O)c2ccc3CC4(Cc3c2)C(=O)Nc2ncccc42)C1=O)c1cccc(F)c1F |r| Show InChI InChI=1S/C29H26F2N4O3/c1-35-15-18(20-4-2-6-22(30)24(20)31)9-10-23(27(35)37)33-26(36)16-7-8-17-13-29(14-19(17)12-16)21-5-3-11-32-25(21)34-28(29)38/h2-8,11-12,18,23H,9-10,13-15H2,1H3,(H,33,36)(H,32,34,38)/t18-,23-,29?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel...				US Patent US9833448 (2017) BindingDB Entry DOI: 10.7270/Q2BP052K
					More data for this Ligand-Target Pair