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SMILES: Cc1ncc(C)n2nc(CCc3nc4ccccc4cc3F)nc12

InChI Key: InChIKey=MZALWOUKEXETFR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362567   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362567 (US10562916, Compound 127 | US9834564, Compound 127) Show SMILES Cc1ncc(C)n2nc(CCc3nc4ccccc4cc3F)nc12 Show InChI InChI=1S/C18H16FN5/c1-11-10-20-12(2)18-22-17(23-24(11)18)8-7-16-14(19)9-13-5-3-4-6-15(13)21-16/h3-6,9-10H,7-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362567 (US10562916, Compound 127 | US9834564, Compound 127) Show SMILES Cc1ncc(C)n2nc(CCc3nc4ccccc4cc3F)nc12 Show InChI InChI=1S/C18H16FN5/c1-11-10-20-12(2)18-22-17(23-24(11)18)8-7-16-14(19)9-13-5-3-4-6-15(13)21-16/h3-6,9-10H,7-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc. US Patent					Assay Description The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...				US Patent US9834564 (2017) BindingDB Entry DOI: 10.7270/Q2FF3VN4
					More data for this Ligand-Target Pair