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SMILES: Cn1c(CCc2ccc3cnccc3n2)nc2c1ccc1cccnc21

InChI Key: InChIKey=GYWUTHCQZYWJIQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362603   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362603 (US10562916, Compound 163 | US9834564, Compound 163) Show SMILES Cn1c(CCc2ccc3cnccc3n2)nc2c1ccc1cccnc21 Show InChI InChI=1S/C21H17N5/c1-26-18-8-5-14-3-2-11-23-20(14)21(18)25-19(26)9-7-16-6-4-15-13-22-12-10-17(15)24-16/h2-6,8,10-13H,7,9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362603 (US10562916, Compound 163 | US9834564, Compound 163) Show SMILES Cn1c(CCc2ccc3cnccc3n2)nc2c1ccc1cccnc21 Show InChI InChI=1S/C21H17N5/c1-26-18-8-5-14-3-2-11-23-20(14)21(18)25-19(26)9-7-16-6-4-15-13-22-12-10-17(15)24-16/h2-6,8,10-13H,7,9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc. US Patent					Assay Description The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...				US Patent US9834564 (2017) BindingDB Entry DOI: 10.7270/Q2FF3VN4
					More data for this Ligand-Target Pair