BDBM364088 6-[3-[(2-pyrrolidin-1-ylethylamino)methyl]phenyl]pyrido[3,2-d]pyrimidin-4-amine::US9855269, Compound 331

SMILES: Nc1ncnc2ccc(nc12)-c1cccc(CNCCN2CCCC2)c1

InChI Key: InChIKey=TUYJIJHGPPOCGR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364088   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM364088 (6-[3-[(2-pyrrolidin-1-ylethylamino)methyl]phenyl]p...) Show SMILES Nc1ncnc2ccc(nc12)-c1cccc(CNCCN2CCCC2)c1 Show InChI InChI=1S/C20H24N6/c21-20-19-18(23-14-24-20)7-6-17(25-19)16-5-3-4-15(12-16)13-22-8-11-26-9-1-2-10-26/h3-7,12,14,22H,1-2,8-11,13H2,(H2,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair