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SMILES: Cc1ncc(C)n2nc(CCc3cn4ccccc4n3)nc12

InChI Key: InChIKey=HBENBNYEZORWNQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364291   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM364291 (US10570156, Compound 1 | US9856274, Compound 1) Show SMILES Cc1ncc(C)n2nc(CCc3cn4ccccc4n3)nc12 Show InChI InChI=1S/C16H16N6/c1-11-9-17-12(2)16-19-14(20-22(11)16)7-6-13-10-21-8-4-3-5-15(21)18-13/h3-5,8-10H,6-7H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
SUNOVION PHARMACEUTICALS INC. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10570156 (2020) BindingDB Entry DOI: 10.7270/Q2H997MR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM364291 (US10570156, Compound 1 | US9856274, Compound 1) Show SMILES Cc1ncc(C)n2nc(CCc3cn4ccccc4n3)nc12 Show InChI InChI=1S/C16H16N6/c1-11-9-17-12(2)16-19-14(20-22(11)16)7-6-13-10-21-8-4-3-5-15(21)18-13/h3-5,8-10H,6-7H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Rheinische Friedrich-Wilhelms-Universitat Bonn					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				J Med Chem 48: 7688-707 (2005) BindingDB Entry DOI: 10.7270/Q2Z89FPT
					More data for this Ligand-Target Pair