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SMILES: Cn1c(CCc2cn3ccncc3n2)nc2c1ccc1ncccc21

InChI Key: InChIKey=KZCFFCWSRZPCOH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364349   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM364349 (US10570156, Compound 31 | US9856274, Compound 31) Show SMILES Cn1c(CCc2cn3ccncc3n2)nc2c1ccc1ncccc21 Show InChI InChI=1S/C19H16N6/c1-24-16-6-5-15-14(3-2-8-21-15)19(16)23-17(24)7-4-13-12-25-10-9-20-11-18(25)22-13/h2-3,5-6,8-12H,4,7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
SUNOVION PHARMACEUTICALS INC. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10570156 (2020) BindingDB Entry DOI: 10.7270/Q2H997MR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM364349 (US10570156, Compound 31 | US9856274, Compound 31) Show SMILES Cn1c(CCc2cn3ccncc3n2)nc2c1ccc1ncccc21 Show InChI InChI=1S/C19H16N6/c1-24-16-6-5-15-14(3-2-8-21-15)19(16)23-17(24)7-4-13-12-25-10-9-20-11-18(25)22-13/h2-3,5-6,8-12H,4,7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
Rheinische Friedrich-Wilhelms-Universitat Bonn					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				J Med Chem 48: 7688-707 (2005) BindingDB Entry DOI: 10.7270/Q2Z89FPT
					More data for this Ligand-Target Pair