BDBM364482 (R or S)-N-[6-(2,2-difluoro-1- hydroxyethyl)-2-phenyl-2H- indazol-3-yl]-2-fluoro-5-pyrimidin- 2-yl-4-(trifluoromethyl)benzamide, isomer A::US9862707, Example 56::US9862707, Example 57
SMILES: OC(C(F)F)c1ccc2c(NC(=O)c3cc(-c4ncccn4)c(cc3F)C(F)(F)F)n(nc2c1)-c1ccccc1
InChI Key: InChIKey=KGAQXHWMFVCAJX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM364482 ((R or S)-N-[6-(2,2-difluoro-1- hydroxyethyl)-2-phe...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Rheinische Friedrich-Wilhelms-Universitat Bonn | Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ... | J Med Chem 48: 7688-707 (2005) BindingDB Entry DOI: 10.7270/Q2FB5576 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM364482 ((R or S)-N-[6-(2,2-difluoro-1- hydroxyethyl)-2-phe...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rheinische Friedrich-Wilhelms-Universitat Bonn | Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ... | J Med Chem 48: 7688-707 (2005) BindingDB Entry DOI: 10.7270/Q2FB5576 | |||||||||||
More data for this Ligand-Target Pair |