BDBM364981 6-{3,4-cis-4-[1-(2-Azetidin-1-yl-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-3-fluoro-piperidin-1-yl}-5-chloro-pyrimidin-4-ylamine::US9867826, Compound 10

SMILES: Nc1ncnc(N2CC[C@H]([C@@H](F)C2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1Cl

InChI Key: InChIKey=BPJUPXXKAPKTBS-QAPCUYQASA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364981   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM364981 (6-{3,4-cis-4-[1-(2-Azetidin-1-yl-ethyl)-4-(4-fluor...) Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](F)C2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1Cl |r| Show InChI InChI=1S/C24H25ClF5N7/c25-20-21(31)32-13-33-23(20)36-7-4-15(18(27)11-36)22-34-19(12-37(22)9-8-35-5-1-6-35)14-2-3-17(26)16(10-14)24(28,29)30/h2-3,10,12-13,15,18H,1,4-9,11H2,(H2,31,32,33)/t15-,18+/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description AKT: A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose respon...				J Med Chem 50: 3651-60 (2007) BindingDB Entry DOI: 10.7270/Q2SJ1NXM
					More data for this Ligand-Target Pair
P70S6K (T412E) (Homo sapiens (Human))	BDBM364981 (6-{3,4-cis-4-[1-(2-Azetidin-1-yl-ethyl)-4-(4-fluor...) Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](F)C2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1Cl |r| Show InChI InChI=1S/C24H25ClF5N7/c25-20-21(31)32-13-33-23(20)36-7-4-15(18(27)11-36)22-34-19(12-37(22)9-8-35-5-1-6-35)14-2-3-17(26)16(10-14)24(28,29)30/h2-3,10,12-13,15,18H,1,4-9,11H2,(H2,31,32,33)/t15-,18+/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...				J Med Chem 50: 3651-60 (2007) BindingDB Entry DOI: 10.7270/Q2SJ1NXM
					More data for this Ligand-Target Pair